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6 GRAINS ACCURATE 5 FREE
We also show that the resulting free energies of the side chains are sufficiently accurate for de novo folding of some proteins.Ĭitation: Jumper JM, Faruk NF, Freed KF, Sosnick TR (2018) Accurate calculation of side chain packing and free energy with applications to protein molecular dynamics. Our method enables rapidly equilibrating coarse-grained simulations that can nonetheless contain significant molecular detail. We demonstrate state-of-the-art accuracy for predicting χ 1 rotamer states while consuming only milliseconds of CPU time. We also introduce a novel, maximum-likelihood method to parameterize the side chain interactions using protein structures. Our method, termed Upside, employs a reduced model involving the three backbone atoms, along with the carbonyl oxygen and amide proton, and a single (oriented) side chain bead having multiple locations reflecting the conformational diversity of the side chain’s rotameric states. This computation results in extremely rapid equilibration and sampling of the Boltzmann distribution. The side chain free energy is computed on the fly, allowing the protein backbone dynamics to traverse a greatly smoothed energetic landscape. In analogy with the adiabatic Born-Oppenheimer approximation for electronic structure, the protein backbone dynamics are simulated as preceding according to the dictates of the free energy of an instantaneously-equilibrated side chain potential.
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Remember guys shooting Prairie dogs with handguns like Encores, Contenders, ect make killing hits over 300 yards with them with 15 inch and shorter barrels.To address the large gap between time scales that can be easily reached by molecular simulations and those required to understand protein dynamics, we present a rapid self-consistent approximation of the side chain free energy at every integration step. I really cannot see what difference a shorter barrel will make for longer range shooting! Yea you loose a couple 100 FPS maybe but if your gun is sighted in for longer ranges that couple hundred FPS should not make that much difference expecially with these bullets haveing such good penitration and BC. I used a 6.5X.284 with that combo and didn't strike out.The cartridges are quite similar. That 160 will still produce a good trajectery. The slower powders in that length barrel are going to give you a lot more boom but not much more velocity. The large sectional density at modestly high velocities should be a good marriage. RN with powders in the 4895 to BL-C-2 burning rates should be a winning combination. 600 or 660 ( short barrels) are not seriously considered as long range rifles, the 160 gr. Varmint grade accurate! Must be why they are so popular.īecause the Mod. There went 15 lbs of steaks/hamburger.Īnd all of my 6.5 bores shoot very accurately. Upon field cleaning tho, I also saw that we lost the entire oft shoulder to being blood shot. I watched it fall in the scope, not loosing site picture because lack of recoil. Some guys would have loved that performance.Įven at 300 yds, it dropped the deer instantly. The only negative one I have anything grumbles about was the Nosler Ballistic tip. I have taken 6 or so deer with 100 grain bullets from all manufacturers. Even the 100 grainers available have done a great job for me. ( in a pinch)Ħ.5 bullets all work based on high sectional density and good aerodynamic design. The 6.5 Rem Mag is basically a 6.5/06 in different clothes, so it should work fine. I leave out the 264 Mag with that statement as I have no experience using that combo on anything. So even the varmint bullets work in a pinch in the 6.5 bore. These deer were the size of antelope but the 90 grain TNT dropped them just fine with a lung shot. To put them down humainely, instead of them suffering, all I had with me was a 260 loaded with 90 grain Speer TNT bullets. Though I don't recommend it for the average shooter, I have had to dispatch several deer that have been hit by cars and have staggered off into a field. 23 February 2005, 23:17 seafire/B17GThere is no real "bad" bullet for the 6.5 bore, unless one takes a light bullet with some fragility and push it at magnum velocities at short impact distances.